|Teacher/Coordinator: Dr Matthew Naylor|
Classes: Two 1-hour lectures and one 3-hour practical or one 2-hour tutorial per week.
Assessment: One 2-hour exam, 3 practical assignments (100%)
|The aim of this unit of study is to examine in depth the structure and function of the cardiovascular system at the organ system, cellular and molecular levels. There is a particular focus on exercise physiology and the way in which the heart, circulation and skeletal muscles contribute to the limits of sporting achievement. The excitability, contractility and energetics of the heart and blood vessels are studied and the regulation of these organs by local (physical and chemical) factors, hormones and the nervous system are discussed, with emphasis on cellular and molecular mechanisms. At the systemic level, short term (neural) mechanisms controlling the blood pressure and how the system behaves during exercise (including muscle physiology) and other stresses is dealt with. Long term (hormonal) mechanisms regulating blood pressure via the renal control of extracellular fluid volume is also discussed. There is an emphasis in this unit of study on recent advances in cellular and molecular aspects of heart and the blood vessels and the regulation of these organs by local (physical and chemical) factors, hormones and the autonomic nervous system. Lectures will be complemented by practical classes and tutorials that reinforce the theory and emphasise experimental design, data interpretation and presentation.It is recommended that students take PHSI3007 ONLY in combination with PHSI3008.|